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Mtb ATP synthase-IN-1

CAS No. 2642394-38-3

Mtb ATP synthase-IN-1( —— )

Catalog No. M35484 CAS No. 2642394-38-3

Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mtb ATP synthase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
  • Description
    Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.
  • In Vitro
    ——
  • In Vivo
    Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.Animal Model:Male CD-1 mouseDosage:50 and 5 mg/kg Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result:Exhibited good metabolic stability and acceptable oral bioavailability.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ATPase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2642394-38-3
  • Formula Weight
    323.3
  • Molecular Formula
    C17H13N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (386.64 mM; Ultrasonic )
  • SMILES
    O=C1C(=O)C(NCC2=NC=CC=C2)=C1NC3=CC=C4OCOC4=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li P, et al. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur J Med Chem. 2020;206:112538.?
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